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Bond-Selective Imaging of Cells by Mid-Infrared Photothermal Microscopy in High Wavenumber Region
Bai, Yeran; Zhang, Delong; Li, Chen; Liu, Cheng; Cheng, Ji-Xin; jxcheng@bu.edu
2017
Source PublicationJ. Phys. Chem. B
Volume121Issue:44Pages:10249
AbstractUsing a visible beam to probe the thermal effect induced by infrared absorption, mid-infrared photothermal (MIP) microscopy allows bond-selective chemical imaging at submicron spatial resolution. Current MIP microscopes cannot reach the high wavenumber region due to the limited tunability of the existing quantum cascade laser source. We extend the spectral range of MIP microscopy by difference frequency generation (DFG) from two chirped femtosecond pulses. Flexible wavelength tuning in both C-D and C-H regions was achieved with mid-infrared power up to 22.1 mW and spectral width of 29.3 cm(-1). Distribution of fatty acid in live human lung cancer cells was revealed by MIP imaging of the C-D bond at 2192 cm(-1).
SubtypeArticle
Department联合
DOI10.1021/acs.jpcb.7b09570
Funding OrganizationKeck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37] ; Keck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37] ; Keck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37] ; Keck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37]
Indexed BySCI
Funding OrganizationKeck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37] ; Keck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37] ; Keck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37] ; Keck Foundation Science and Engineering grant; UCAS Joint Ph.D. Training Program [UCAS [2015]37]
WOS IDWOS:000415140000007
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Document Type期刊论文
Identifierhttp://ir.siom.ac.cn/handle/181231/27937
Collection高功率激光物理国家实验室
Corresponding Authorjxcheng@bu.edu
Affiliation中国科学院上海光学精密机械研究所
Recommended Citation
GB/T 7714
Bai, Yeran,Zhang, Delong,Li, Chen,et al. Bond-Selective Imaging of Cells by Mid-Infrared Photothermal Microscopy in High Wavenumber Region[J]. J. Phys. Chem. B,2017,121(44):10249.
APA Bai, Yeran,Zhang, Delong,Li, Chen,Liu, Cheng,Cheng, Ji-Xin,&jxcheng@bu.edu.(2017).Bond-Selective Imaging of Cells by Mid-Infrared Photothermal Microscopy in High Wavenumber Region.J. Phys. Chem. B,121(44),10249.
MLA Bai, Yeran,et al."Bond-Selective Imaging of Cells by Mid-Infrared Photothermal Microscopy in High Wavenumber Region".J. Phys. Chem. B 121.44(2017):10249.
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